According to Nadiadwala, 'It will be an international love story on a lavish scale.' Kumar plays a Hollywood stuntman in the film and Kapoor plays a high-society girl. It is the seventh time Kumar and Kapoor are paired on-screen. Later that month Kareena Kapoor was signed on to play the female lead. In November 2007, producer Sajid Nadiadwala signed on actor Akshay Kumar to play the lead role in his film.

Ashwin Mushran as Parmeet Sandhu, Kamini's brother.

Kahkashan Patel as Nimrita 'Nim' Rai, Simrita's sister.

Kirron Kher as Dolly Bindra, Simrita and Nimrita's aunt.

Vindu Dara Singh as Gulshan 'Tiger' Shergill, Viraj's brother.

Amrita Arora as Kamini Sandhu, Simrita's friend.

Aftab Shivdasani as Lavanya 'Lucky' Shergill, Viraj's brother.Kareena Kapoor as Simrita 'Sim' Rai a.k.a.The two embrace and go off together in the car sharing a few passionate kisses. At first, Denise is upset but then tells Viraj to go to Simrita. Upon realising her mistake, Simrita helps Lucky and Kamini reconcile and decides to confess her love for Viraj at the wedding ceremony. Several days later, he proposes to Denise Richards in an attempt to forget about Simrita. Following the surgery, Viraj overhears the truth and leaves. Several days later, Simrita is successful in removing the watch from Viraj's stomach. By this time, Viraj is secretly beginning to fall in love with Simrita. During one such process, which fails, it becomes clear that Simrita is bitter about her perceived unfaithfulness of the two most prominent men from her childhood: her divorced father and her elder sister's ex-husband. Simrita tries various ways of getting the watch out. After the surgery, while looking at the X-rays, she is horrified to discover that the watch on her wrist has accidentally ended up in Viraj's stomach.

Much to each other's irritation, Simrita is given the charge to perform surgery on Viraj. Viraj gets seriously hurt in an accident at work and is brought for emergency surgery to the hospital where Simrita is an intern. The pendant hangs from a bracelet on her wrist. Upon returning home, Simrita is given a watch pendant by her aunt Dolly to wear as a good luck charm.

Meanwhile, Simrita and Viraj keep bumping into each other when they both travel to Italy independently the former to make some quick cash as a model to pay her medical bills, and the latter, with Lucky, to chill out and take a vacation from all of the marital stress Lucky has been facing back home. Lucky tries to make love with Kamini but she never lets him come near her. Simrita keeps on telling Kamini that all men are the same and that all they want is sex.

The plan backfires out of a police raid and Kamini and Lucky end up in divorce court where the judge puts them on a three-month probation and marriage counselling. This results in a hilarious scene at a local disco bar, where Viraj lures Kamini with the hope of her finding Lucky with a 'girlfriend' that he has planted in the lap of Lucky in order to make Kamini jealous. Viraj, upon hearing about this new development, tries to do the exact opposite. She is sure, Lucky will not be able to do so and this will prove to Kamini that Lucky was just another low-class male, like all others, and her claims of him being different from most men are unfounded. Simrita convinces Kamini to test out her theory that men are after only one thing, by forcing Lucky to delay their marriage vows for three months. Both have a very low opinion of the opposite sex, and staunchly believe marriage is not the way to go for the two newlyweds, whom they try to discourage from proceeding further. When Hollywood stuntman Viraj Shergill and medical student Simrita Rai come across each other at his brother Lucky's and her best friend Kamini Sandhu's hastily planned wedding ceremony, they instantly develop a dislike for each other.

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